Pharmacokinetics and Adverse Reaction in Methotrexate Therapy of Osteosarcoma.
نویسندگان
چکیده
منابع مشابه
Diurnal Variation of Methotrexate Pharmacokinetics in Adults With Osteosarcoma
17 Abstract: The daytime and nighttime dispositions of high dose (12 g/m) methotrexate were examined in 8 osteosarcoma patients. The plasma and renal clearances, urine pH values and area under the curves were compared. The plasma clearance of methotrexate tended to fall after it was administered at (from 1.74±0.06 ml/min/kg to 0.47±0.01 ml/min/kg, p<0.05). Renal clearance (from 2.48±0.54 ml/min...
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Two patients with osteogenic sarcoma were treated with high-dose methotrexate (MTX) followed by leucovorin 'rescue'. Profiles of MTX clearance from plasma and erythrocytes were obtained. Clearance of the drug from plasma during the first 36 hours appears to be biphasic with the first phase of elimination of the drug being appreciably more rapid than the second phase. The drug had also incorpora...
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15 صفحه اولMechanisms of methotrexate resistance in osteosarcoma.
High-dose methotrexate is a major component of current protocols for the treatment of osteosarcoma, but some tumors seem to be resistant. Potential mechanisms of resistance include decreased transport through the reduced folate carrier (RFC) and increased expression of dihydrofolate reductase (DHFR). To investigate methotrexate resistance, tumors were obtained from 42 patients with high-grade o...
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Hypersensitivity reactions to methotrexate are rare, but have been reported. Methotrexate has shown activity against many malignancies, and omission of methotrexate therapy may increase the risk of cancer-related death in some patients. Therefore, rechallenging patients with methotrexate following hypersensitivity may be beneficial. We report a case of a child with metastatic osteosarcoma who e...
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ژورنال
عنوان ژورنال: Japanese Journal of Hospital Pharmacy
سال: 2000
ISSN: 2185-9477,0389-9098
DOI: 10.5649/jjphcs1975.26.116